Prognostic value of endotoxicosis criteria in the diagnosis of acute renal injury

Materialy VIII Vserossijskoj konferencii s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka» Pub Date : 2021-12-13 DOI:10.34014/mpphe.2021-57-60

A. P. Vlasov, V. Ryazantsev, T. A. Muratova, M. V. Volkova, N.Yu. Stepanov, I. Mashnin

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Abstract

In order to find informative statically significant laboratory criteria for endotoxicosis in the diagnosis of acute renal injury, a clinical and biochemical study of 40 patients with acute renal injury developed against the background of renal urological and extrarenal surgical pathology was conducted. The results of the study demonstrate pronounced changes in the mechanisms of antioxidant protection that develop in patients with acute renal injury. Deviations from the initial level of the studied criteria are interrelated with many links of pathogenesis, where one of the central links is ischemia of the renal parenchyma. The progression of endogenous intoxication, taking into account the data obtained, confirmed by a decrease in prooxidant protection contributes to the progression of intrarenal changes, aggravating functional changes in renal and extrarenal injuries. Key words: significance of endotoxicosis criteria, acute renal injury, endotoxicosis, serum creatinine, glomerular filtration rate.

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内毒素中毒标准在急性肾损伤诊断中的预后价值

为了寻找内毒素中毒在急性肾损伤诊断中具有统计学意义的实验室标准，我们对40例急性肾损伤患者进行了以肾泌尿外科和肾外外科病理学为背景的临床和生化研究。研究结果表明，急性肾损伤患者抗氧化保护机制发生显著变化。偏离研究标准的初始水平与发病机制的许多环节有关，其中一个中心环节是肾实质缺血。考虑到所获得的数据，内源性中毒的进展，由促氧化保护的减少证实，有助于肾内变化的进展，加重肾和肾外损伤的功能变化。关键词:内毒素标准意义，急性肾损伤，内毒素，血清肌酐，肾小球滤过率。

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Materialy VIII Vserossijskoj konferencii s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka»

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