[Effect of magnesium ions on the functional state of postsynaptic membrane by modulation of the level of non-quantal secretion of the mediator].

Abstract

The role of non-quantal secretion (NS) of acetylcholine (ACh) in shortening of miniature end-plate currents (MEPC) after initial prolongation of MEPC due to acetylcholinesterase (AChE) inhibition was studied in the mouse diaphragm muscle under the voltage clamp conditions. Elevation of NS level by removal of magnesium ions from solution accelerated the shortening effect. After elimination of NS due to an increase of magnesium concentration up to 3 mmol/l the shortening of MEPC was absent. It was suggested that after AChE inhibition the magnesium ions in physiological range of concentrations can modulate the desensitization development on postsynaptic membranes by NS level regulation.