Multipl Myelom Tanılı Hastaların Sitogenetik Özellikleri ve Prognoza Etkisi

Abstract

Objective: In our study, we aimed to evaluate the effect of cytogenetic features of patients with multiple myeloma (MM) on prognosis in our center. Patients and Methods: The study was designed retrospectively. Age and gender data, laboratory data, subtypes of MM, International Scoring System (ISS) and Revised ISS (R-ISS) stages and cytogenetic characteristic of patients were investigated. Patients were divided into two risk groups according to characteristic of cytogenetics: standart risk and high risk. Survival analysis was examined. Results: 83 of 112 patients diagnosed with multiple myelom whose genetic characteristics were studied were included in the study. 15.7% of these patients had high risk cytogenetics. The 5-year overall survival of all patients was 50%. The 3-year overall survival was 25% in the high-risk group and 75% in the standard-risk group. The median survival was 76 months for standard-risk patients and 28 months for high-risk patients, and this difference was statistically significant (p= 0.004, chi-square: 8.2). Conclusion: Approximately 1/6 of the patients diagnosed with MM have high risk cytogenetics. Overall survival of patients with high-risk cytogenetics was significantly shorter than patients with standard cytogenetics.