Primary Brain Tumors in Childhood

R. Richterová, B. Kolarovszki
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引用次数: 3

Abstract

This chapter offers literary review of most frequently observed brain tumors in child - hood. It offers basics of epidemiology, clinical presentation and diagnostics of most often occurring types of tumors according to new WHO classification of brain tumors from 2016 and emphasizes molecular biological characteristics and role of altered genes and genetic pathways in brain tumor etiology, classification and treatment. This review not only concentrates on gliomas, medulloblastomas and ependymomas, but also offers characterization of other less frequently observed lesions. Each tumor characteristics also contains basics of therapeutical possibilities of these lesions with focus on targeted and individually designed therapy according to molecular and genetic alterations found in tumor tissue sample.
儿童原发性脑肿瘤
本章提供了最常见的儿童脑肿瘤的文献综述。它根据2016年世卫组织新的脑肿瘤分类,提供最常发生的肿瘤类型的流行病学、临床表现和诊断基础知识,并强调分子生物学特征以及改变的基因和遗传途径在脑肿瘤病因、分类和治疗中的作用。这篇综述不仅集中于胶质瘤、髓母细胞瘤和室管膜瘤,而且还提供了其他不常观察到的病变的特征。每个肿瘤特征还包含这些病变治疗可能性的基础知识,重点是根据肿瘤组织样本中发现的分子和遗传改变进行靶向和单独设计的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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