Investigation Of Thyroid Hormones, Diabetic Parameters And Other Anthropometric Parameters In The Sera Of Young Women With 2 Diabetes Mellitus

Abstract

Diabetes mellitus: are a group of metabolic disease described by constant hyperglycaemia with changes in proteins, lipid, and carbohydrate caused by insulin secretion deficiencies. The purpose of the study is to check the level of anthropometric variables (Age, Body Mass Index, Waist circumference and waist to hip ratio), the variables to study T2DM ( FBS, HbA1C, Insulin and HOMA-IR) in other hand, study of thyroid hormones ( T3,T4) and pituitary hormone (TSH)  that effect on and effected by T2DM. This study involved collecting (140) samples (80) patients females diagnosed with T2DM and (60) samples of healthy females, all samples were collected from subjects of the same age group P?0.05 was used to determine whether the study's findings were significant. The difference in age between the two groups was not significant (P>0.05), while anthropometric characteristics showed highly significant differences (P<0.01) for the other parameters the level of glucose, insulin, HbA1C, HOMA-IR, T4 and TSH were substantially higher (P<0.05) in patients females than in control, T3 level was non-significant (P>0.05) effect. From the collected information it is clear that weight and it is variables have a big effect and conceder as a reason for T2DM, the study of FBS and HbA1C is done to give evidence  that the harm happened in the pancreas makes the body unable to digest glucose. The insulin is secreted in patients more than control and it  insured that the reason made it unable to work is the activity of insulin resistance , the interruption of some auto immune effect causes the elevation in IR and that’s  makes the insulin unable to do his job in the body and decrease the level of glucose. The level of TSH raised and T4 decreased in T2DM patients and that back to the fact that the thyroid hormones join in the metabolism of glucose and the dysfunction in the work of this gland effect by several ways on T2DM.