CONTENTS OF ENERGY HOMEOSTASY INDICATORS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH CONCOMITANT TYPE 2 DIABETES MELLITUS

Abstract

coronary heart is of the most common cardiovascular diseases in Europe Type 2 diabetes mellitus (DM) is a significant risk factor that can provoke the development of acute myocardial infarction (AMI) and affect the occurrence of adverse complications of AMI It is known that adipose tissue produces many adipocytokines, which are involved in carbohydrate and lipid metabolism, the formation of insulin resistance and inflammatory processes. However, adropin and irisin in the pathogenesis of AMI, depending on the presence of type 2 DM, are currently insufficiently studied. Adropin and irisin have an effect on carbohydrate, lipid homeostasis associated with type 2 DM [3]. The study examined 90 patients with AMI, depending on the presence of concomitant type 2 DM, who were treated at the State Institution «National Institute of Therapy named after L.T. Malaya National Academy of Medical Sciences of Ukraine» and in the Kharkiv Clinical Hospital on railway transport №1. Adropin and irisin were determined by enzyme-linked immunosorbent assay using a set of reagents «Human Adropin», «Human Fibronectin type III domain-containing protein 5 (FNDC5)» (Elabscience, USA) according to the specified instruction. Statistical computer processing of the survey results was performed using the program «IBM SPPS Statistics 27.0».