H. Uehara, K. Satoh, Nagisa Komokata, Yohei Tokita, Mitsue Nishiyama, Maiko Iida, Junko Ishikawa, Kazuo Ogawa, Masahiro Yamamoto
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引用次数: 0
Abstract
In this article, we propose an alternative criterion for evaluating parallelism in parallel-line assays at the subject level. Unlike another recently proposed criterion (“ISP”; Uehara et al., 2016), this is a single criterion concerning the quantile of intrasubject slope ratio, which is straightforward to interpret. Two one-sided tolerance limits for a linear combination of the control and test slopes are developed as metrics for the evaluation of discrepancy from the ideal intrasubject parallelism. The proposed metrics are exemplified using data from two ex vivo parallel-line experiments, and their characteristics are investigated through Monte Carlo simulations.
在这篇文章中,我们提出了另一个标准,以评估平行线分析在主题水平的并行性。不像最近提出的另一个标准(“ISP”;Uehara et al., 2016),这是关于主体内斜率比分位数的单一标准,解释起来很简单。两个单侧公差限制的线性组合的控制和测试斜率被开发作为衡量差异的指标,从理想的主体内平行度。利用两个离体平行线实验的数据对所提出的指标进行了举例说明,并通过蒙特卡罗模拟研究了它们的特性。