Case Report: A Rare Case of Marchiafava Bignami Disease

Abstract

Marchiafava-Bignami illness is a rare toxic disease that mostly affects chronic alcoholics and causes progressive demyelination and necrosis of the corpus callosum. The process may spread laterally into surrounding white matter and, on rare occasions, into the subcortical areas. We describe the MR imaging findings in two individuals who presented with acute alcohol-related disorders and discuss the hallmarks of the disease and other acute alcohol-related diseases.