A method to quantitatively evaluate changes in tremor during deep brain stimulation surgery

Abstract

Deep Brain Stimulation (DBS) surgery is used increasingly as a symptomatic treatment for patients with movement related neuro-degenerative disorders. However, the method of intraoperative symptom evaluation is subjective. This paper proposes a method to quantitatively evaluate tremor by measuring the acceleration of the patient's wrist during the surgery. The results of applying the method to 2 patients suggest that the acceleration measurements are very sensitive to the change in the tremor and that they can be used to identify clinically effective stimulation amplitudes. By collecting acceleration data from DBS surgeries for many patients, we hope to add more knowledge to the mechanisms of deep brain stimulation.