An experimental study to evaluate the antidotal activity of Neeli Moola (Indigofera tinctoria) Kalka w.s.r to haematological parameters in Vatsanabha (Aconitum ferox ) induced toxicity

Sreelakshmi A, S. R., Sudhakara Bhat, S. K, C. Hebbar
{"title":"An experimental study to evaluate the antidotal activity of Neeli Moola (Indigofera tinctoria) Kalka w.s.r to haematological parameters in Vatsanabha (Aconitum ferox ) induced toxicity","authors":"Sreelakshmi A, S. R., Sudhakara Bhat, S. K, C. Hebbar","doi":"10.21760/jaims.5.6.13","DOIUrl":null,"url":null,"abstract":"Background: Vatsanabha is a potent cardiac poison comes under the category of Mahavisha with its main active principles aconitine, picraconine and pseudaconine. In the literatures there are descriptions about toxicants and in some traditional Malayalam textbooks antidotes has been explained under the concept “Prathyoushadha”. Neeli Moola has been mentioned as a Prathyoushadha for Vatsanabha poisoning in a renowned textbook „Visha Vaidya Jyotsnika‟. Hence to evaluate the antidotal activity in Vatsanabha poisoning, Neeli Moola Kalka has been used and the haematological parameters were analyzed to screen the results. Methods: Wistar strain albino rats were used in this study which were divided into 3 groups, normal control, toxic control and the test drug group. The duration of the study was 28 days .The data generated was mentioned as Mean±SEM. Difference among the groups was assessed by employing one way ANOVA followed by Dunnet‟s mul tiple „t‟ test. Results: Reversible action has been observed after the administration of Neeli Moola Kalka in the hematological parameters which has shown toxicity changes due to administration of Vatsanabha. Conclusion: Neeli Moola Kalka is having mild to moderate antidote effect in Vatsanbha induced toxicity.","PeriodicalId":153289,"journal":{"name":"Journal of Ayurveda and Integrated Medical Sciences (JAIMS)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2020-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Ayurveda and Integrated Medical Sciences (JAIMS)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21760/jaims.5.6.13","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Vatsanabha is a potent cardiac poison comes under the category of Mahavisha with its main active principles aconitine, picraconine and pseudaconine. In the literatures there are descriptions about toxicants and in some traditional Malayalam textbooks antidotes has been explained under the concept “Prathyoushadha”. Neeli Moola has been mentioned as a Prathyoushadha for Vatsanabha poisoning in a renowned textbook „Visha Vaidya Jyotsnika‟. Hence to evaluate the antidotal activity in Vatsanabha poisoning, Neeli Moola Kalka has been used and the haematological parameters were analyzed to screen the results. Methods: Wistar strain albino rats were used in this study which were divided into 3 groups, normal control, toxic control and the test drug group. The duration of the study was 28 days .The data generated was mentioned as Mean±SEM. Difference among the groups was assessed by employing one way ANOVA followed by Dunnet‟s mul tiple „t‟ test. Results: Reversible action has been observed after the administration of Neeli Moola Kalka in the hematological parameters which has shown toxicity changes due to administration of Vatsanabha. Conclusion: Neeli Moola Kalka is having mild to moderate antidote effect in Vatsanbha induced toxicity.
研究了木楝对乌头中毒血液学指标的解毒作用
背景:大毒是一种强效的心脏毒药,属于大毒的范畴,其主要活性成分是乌头碱、苦毒碱和假乌头碱。在文献中有关于毒物的描述,在一些传统的马拉雅拉姆教科书中,解毒剂被解释为“Prathyoushadha”的概念。Neeli Moola在著名的教科书《Visha Vaidya Jyotsnika》中被提及为Vatsanabha中毒的Prathyoushadha。因此,为了评价其对Vatsanabha中毒的解毒作用,我们采用了Neeli Moola Kalka,并对血液学参数进行了分析筛选。方法:以Wistar系白化大鼠为研究对象,将其分为正常对照组、中毒对照组和给药组。研究持续时间为28天,所得数据以Mean±SEM表示。采用单因素方差分析和Dunnet多重“t”检验来评估组间差异。结果:在给药后观察到可逆性作用,在血液学参数显示毒性变化,由于给药Vatsanabha。结论:枇杷膏有轻、中度解毒作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信