{"title":"Inhibition of Formalin Induced Paw Edema in Rats by Various Fractions/Extracts of Bryophyllum pinnatum","authors":"R. Gupta, M. Lohani, R. Vishwakarma","doi":"10.15415/jptrm.2019.72008","DOIUrl":null,"url":null,"abstract":"Traditionally, Bryophyllum pinnatum is used in the management of arthritis and inflammatory diseases. However, B. pinnatum has not been analysed previously for anti-inflammatory activity. Hence, this study is designed to determine the anti-inflammatory effects of various fractions of B. pinnatum leaf extract using rat model of formalin-induced paw edema. Treatment with various fractions showed marked decrease in formalin-induced paw volume and edema in rats. The results of BPAAF treatment were comparable to standard drug, diclofenac. These results indicate that B. pinnatum could be developed as ant-inflammatory drug after further studies.","PeriodicalId":382729,"journal":{"name":"Journal of Pharmaceutical Technology, Research and Management","volume":"29 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Technology, Research and Management","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15415/jptrm.2019.72008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Traditionally, Bryophyllum pinnatum is used in the management of arthritis and inflammatory diseases. However, B. pinnatum has not been analysed previously for anti-inflammatory activity. Hence, this study is designed to determine the anti-inflammatory effects of various fractions of B. pinnatum leaf extract using rat model of formalin-induced paw edema. Treatment with various fractions showed marked decrease in formalin-induced paw volume and edema in rats. The results of BPAAF treatment were comparable to standard drug, diclofenac. These results indicate that B. pinnatum could be developed as ant-inflammatory drug after further studies.