Multiple Extramedullary Plasmacytomas Of Diaphragm And Chest Wall

Abstract

Extramedullary plasmacytoma accounts for 3% of all plasma cell neoplasms. These tumors have been documented in the gastrointestinal tract, thyroid, salivary glands, lungs, lymphnode and skin. However, multiple plasmacytoma involving the diaphragm and chest wall is rare. We report a case in a 45 year old male who presented with right posterio-lateral, painless, chest wall tumor involving the 9th rib and infiltrating the parietal pleura. 3 additional nodules were noted in the diaphragm. Microscopy revealed a tumor composed of abnormal plasma cells which were positive for CD 79a, CD 138 & MUM 1 antibodies. The tumor cells also showed monotypic immunoreactivity for lambda light chains.