[Changes in the sensitivity of mice to the action of gamma irradiation by Viscum album L. polysaccharides].

Radiobiologiia Pub Date : 1992-11-01
A A Narimanov, O I Popova, D A Murav'eva
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引用次数: 0

Abstract

The influence of water-soluble polysaccharides of Viscum album L. on the survival of mice subjected to whole-body gamma-irradiation has been investigated. Polysaccharides were shown to exert a radioprotective effect which was a function of both the radiation dose and the drug dose and time of its injection. The maximum radioprotective efficacy of polysaccharides was observed after their injection 15 min before irradiation. A single intraperitoneal administration of polysaccharides (25 mg/kg) before irradiation with LD50/30 and LD100/10-12 increased the 60-day survival rate up to 95% and 27% respectively. The postirradiation injection of polysaccharides prevented death of 80% of mice given LD50 and increased the average life expectancy of animals irradiated with absolutely lethal doses.

[粘多糖对γ辐射作用小鼠敏感性的变化]。
研究了粘多糖对全身γ辐照小鼠存活的影响。多糖具有一定的辐射防护作用,其作用与剂量和注射时间有关。多糖在照射前15 min注射后,其防辐射效果达到最大。在LD50/30和LD100/10-12照射前单次腹腔注射多糖(25 mg/kg),可使60天存活率分别提高95%和27%。辐射后注射的多糖阻止了80%的LD50小鼠的死亡,并增加了绝对致死剂量照射动物的平均预期寿命。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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