{"title":"Liver and brain DNA contents in acute soman intoxication.","authors":"F Skopec, J Bajgar","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Contents of DNA in the liver and brain parts (cerebellum, pons, hemispheres) of the rat following acute intoxication with soman (i. m., 32 micrograms/kg) were studied. Statistically significant increase of DNA concentrations in the liver and decrease in the hemispheres 1 and 3 hours after the intoxication was demonstrated; in other brain parts studied, no changes were detected. The blood acetylcholinesterase activity was diminished 1 hour after the injection of soman and it was statistically significant 3 days following poisoning. In rats pretreated with atropinee (i. m., 200 mg/kg) and intoxicated with higher dose of soman (i. m., 50 micrograms/kg), specific activity of incorporation of radiolabelled thymidine into DNA was significantly decreased in the liver only. The results suggested that soman except cholinergic effects also influenced metabolism of nucleic acids.</p>","PeriodicalId":21432,"journal":{"name":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","volume":"35 3","pages":"253-62"},"PeriodicalIF":0.0000,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Contents of DNA in the liver and brain parts (cerebellum, pons, hemispheres) of the rat following acute intoxication with soman (i. m., 32 micrograms/kg) were studied. Statistically significant increase of DNA concentrations in the liver and decrease in the hemispheres 1 and 3 hours after the intoxication was demonstrated; in other brain parts studied, no changes were detected. The blood acetylcholinesterase activity was diminished 1 hour after the injection of soman and it was statistically significant 3 days following poisoning. In rats pretreated with atropinee (i. m., 200 mg/kg) and intoxicated with higher dose of soman (i. m., 50 micrograms/kg), specific activity of incorporation of radiolabelled thymidine into DNA was significantly decreased in the liver only. The results suggested that soman except cholinergic effects also influenced metabolism of nucleic acids.
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