Investigating the Possible Cardio-Protective Effects of Telmisartan against 5-Fluorouracil- Induced Cadiotoxicity in Wister Rats

Abstract

Objective: The present study was designed to investigate the protective effects of telmisartan against 5-FU induced cardiotoxicity in Wister rats. Methods: Thirty-six Wister rats were randomly divided into six groups: I, negative control receiving normal saline (2 ml/kg) orally for 30 successive days; II, positive control receiving normal saline (2ml/kg/day) orally for 25 days, and subsequently received 5-Fluorouracil (5-FU) (20 mg in 2 ml normal saline per kg body weight) once daily by intraperitoneal injection in association with normal saline for a 5 days; III and IV, receiving telmisartan (5mg and 10mg/kg/day) respectively for 30 successive days; V and VI, receiving telmisartan (5 mg and 10 mg/kg/day) orally for 25 days, and subsequently received 5-FU (20 mg in 2ml normal saline per kg body weight) once daily by intraperitoneal injection in association with normal saline for a 5 days respectively. Results: Prophylactic treatment of telmisartan significantly attenuates the serum cardiac troponin T, aspartate Aminotransferase (AST) and alanine. Aminotransferase (ALT) elevation caused by 5-FU-induced cardiotoxicity. Conclusion: results of the present finding suggest that telmisartan may be a useful modulator in mitigating 5-FU induced cardiotoxicity.