The fluorescence study of the quenching of nanoemulsion by protoporphyrin IX (PPIX)

Maurice O Iwunze
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Abstract

Nanoemulsion is a unique and versatile fluid that solubilizes both ionic and non-ionic molecules. It has been used extensively for drug delivery. Nanoemulsion, prepared with water-oil-surfactant and co-surfactant, is fluorescent at or the near IR region of electromagnetic spectrum. However, when protoporphyrin (PPIX), a useful photosensitizer in PDT modality, and a poorly water-soluble compound, is introduced into the nanoemulsion medium, the observed fluorescence of the nanoemulsion is quenched. We have used the steady-state fluorescence technique to study the mechanism of this quenching. It is observed that the interaction between nanoemulsion and PPIX is 1:1 and the interaction constant, Ka, is about 2.37 x 105/mol and the Free energy of interactions, Ga, is -30.66 kJ/mol.
原卟啉IX (PPIX)猝灭纳米乳的荧光研究
纳米乳液是一种独特的多功能流体,可溶解离子和非离子分子。它已被广泛用于药物输送。以水-油表面活性剂和助表面活性剂制备的纳米乳在电磁波谱的红外区或近红外区呈荧光。然而,当原卟啉(PPIX),一种在PDT模式下有用的光敏剂,和一种水溶性差的化合物,被引入到纳米乳液介质中时,观察到的纳米乳液的荧光被猝灭。我们利用稳态荧光技术研究了这种猝灭的机理。结果表明,纳米乳与PPIX的相互作用为1:1,相互作用常数Ka约为2.37 × 105/mol,相互作用的自由能Ga为-30.66 kJ/mol。
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