Synthesis and characterization of some metal ions derived from ciprofloxacin and evaluation of their biological activity

Abstract

This study aims to prepare and characterize a new ligand (LT). This ligand which is derived from ciprofloxacin is able for coordination with the following metal ions: Cu (II), Co (II), Fe (III), Zn (II), Cr (III), Ni (II), and Mn (II); where: LT=4-(3-carboxy-4 - ((3-carboxy-1-cyclopropyl-6-fluoro-7 (piperazine-1yil) quinoline-4 (1h) -ylidene) -6- fluoro-4-1-hydroquinone -7-yl) piperazine-1- were investigated. Analysis of elements, electrical conductivity, magnetic characteristics, melting point, UV-Vis, infrared (IR), 1H nuclear magnetic resonance spectrum, mass spectroscopy, and thermal analysis were employed to describe the synthesized complexes. The TGA has been checked to know the chemical composition of compounds. The measured molar conductivity values refereed to that the non-electrolytic complexes were evaluated to investigate the biological efficacy of the ligand and the synthesized complexes toward the obtained bacteria.