Background

R. Jeyaraj, Sonam Vadera, Z. Low, L. Gluud, M. Morgan
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Abstract

The EASL/AASLD guidelines stipulate that both neomycin and metronidazole may be used as alternatives for the treatment of overt HE, whereas the Italian guidelines state that these antibiotics are currently not recommended, mainly because of their potential systemic toxicity. This study aims to evaluate the utility of aminoglycosides and metronidazole vs. placebo, non-absorbable disaccharides (NAD) and other active treatment, for the management of HE in adults with cirrhosis
背景
EASL/AASLD指南规定,新霉素和甲硝唑均可作为治疗显性HE的替代药物,而意大利指南则指出,目前不推荐使用这些抗生素,主要是因为它们具有潜在的全身毒性。本研究旨在评估氨基糖苷和甲硝唑与安慰剂、不可吸收双糖(NAD)和其他积极治疗在肝硬化成人HE治疗中的效用
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