[The role of fat-soluble vitamins A and E in preventing the biological effects of ionizing radiation in rat tissues].

Radiobiologiia Pub Date : 1992-09-01
A V Paranich, A De Conceçao, E V Buga, A V Kopylov
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引用次数: 0

Abstract

The lipid peroxidation level and the antioxidant system status have been studied by the amount of alpha-tocopherol and the antioxidant activity of homogenates in the brain, liver, heart and somatic muscle of rats given Vitamins A and E, as physiological additives, before and after gamma-irradiation. It has been shown that a new dynamic balance between the parameters under study is rapidly set up after irradiation, which represents a mechanism of rapid adaptation. The radioprotective effect of alpha-tocopherol is more pronounced than that of Vitamin A (particularly in the brain). In most cases, Vitamin A produces, upon irradiation, an unfavourable effect on antioxidative homeostasis.

[脂溶性维生素A和E在防止大鼠组织电离辐射的生物效应中的作用]。
通过研究α -生育酚的含量以及给予维生素A和E作为生理添加剂的大鼠在γ辐照前后脑、肝、心和体肌匀浆的抗氧化活性,研究了脂质过氧化水平和抗氧化系统状态。研究表明,辐照后所研究的参数之间迅速建立起新的动态平衡,这是一种快速适应机制。-生育酚的辐射防护作用比维生素A更明显(尤其是在大脑中)。在大多数情况下,维生素A在照射后会对抗氧化稳态产生不利影响。
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