Thromboxane as diagnostic tool and therapeutic target in cardiovascular disease.

Abstract

Our studies were first directed to improvements in analytical methodology of thromboxane metabolism in man. These methods were then applied in a variety of clinical settings to better define the clinical spectrum and timecourse of platelet related pathomechanisms. They were also applied in studies aiming at optimized therapeutic interventions. Such biochemical guidelines are essential for the optimal planning of future clinical studies.