In vitro α-glucosidase inhibitory activity of compounds isolated from mangrove Lumnitzera littorea leaves

Science and Technology Development Journal Pub Date : 2019-01-07 DOI:10.32508/STDJ.V22I1.1009

T. Nguyen, T. Pham, P. Hansen, P. K. Nguyen

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引用次数: 4

Abstract

Introduction: Lumnitzera littorea grown at CanGio Mangrove Forest has been investigated. The present study reports the isolation, characterization and evaluation of the alpha-glucosidase inhibitory activity of isolated compounds from Lumnitzera littorea leaves. Methods: Their structures were elucidated by spectroscopic methods (including MS, 1D and 2D–NMR) and comparison with values from the literature. From the n-hexane extract, nine compounds including lupeol (1), betulin (2), betulinic acid (3), oleanolic acid (4), corosolic acid (5), -sitosterol (6), beta-sitosterol 3-O- beta-D-glucopyranoside (7), stigmast-5-ene-3beta-O-(6-O-hexadecanoyl-beta-D-glucopyranoside) (8), and stigmast-4-ene-3-one (9) were isolated and identified. Results: The results of the alpha-glucosidase inhibitory activity showed thatcorosolic acid (5) and oleanolic acid (4) were the most potent, with IC50 values of 17.86 +/- 0.42 and 18.82 +/- 0.59 ug/mL, respectively. Five of the other seven compounds exhibited inhibitory activity with IC50 values below 100 ug/mL, and higher than the positive control acarbose (127.64 +/- 0.64 ug/mL).

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红树Lumnitzera littorea叶中化合物体外α-葡萄糖苷酶抑制活性的研究

前言:本文对生长在CanGio红树林中的柳杉进行了调查。本研究报道了从littorea Lumnitzera叶片中分离的化合物的分离、表征和α -葡萄糖苷酶抑制活性的评价。方法:采用质谱、一维、二维核磁共振等波谱方法对其结构进行鉴定，并与文献值进行比较。从正己烷提取液中分离鉴定出九种化合物，分别为鹿皮醇(1)、白桦素(2)、白桦酸(3)、齐墩果酸(4)、花椰果酸(5)、-谷甾醇(6)、-谷甾醇3-o - β - d -葡萄糖苷(7)、柱头甾-5-烯-3-o -(6- o -hexadecanoyl- β - d -glucopyranoside)(8)和柱头甾-4-烯-3-one(9)。结果:α -葡萄糖苷酶抑制活性结果显示，花椰菜酸(5)和齐墩果酸(4)的抑制作用最强，IC50值分别为17.86 +/- 0.42和18.82 +/- 0.59 ug/mL。其中5个化合物的IC50值低于100 ug/mL，均高于阳性对照阿卡波糖(127.64 +/- 0.64 ug/mL)。

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Science and Technology Development Journal

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