AGE-RELATED CHANGES OF HORMONAL HOMEOSTASIS IN POLYCYSTOSIS OF OVARIANS

Abstract

Violation of hormonal homeostasis in polycystic ovary syndrome (PCOS) causes a number of changes in the body of a woman in the postmenopausal period. One of the clinical features of the climacteric syndrome in PCOS is the presence of rare and weak hot flashes, a decrease in the menopausal peak of gonadotropins, and a distinct appearance of local urogenital symptoms. With age, in women with PCOS, a history of insulin resistance and dyslipidaemia predisposes them to early onset of cardiovascular disease and type 2 diabetes. Pathogenetic treatment of women with a history of PCOS in the postmenopausal period should be carried out in order to prevent atherosclerotic and metabolic complications. Keywords: postmenopause, polycystic ovary syndrome, insulin resistance