Diagnose lung cancer by using fluorescence induce from small dose of hematoporphurin

Abstract

Objective: Diagnose lung tumor clinically by using fluorescence induced from small dose of hematoporphyrin. Method : 37 patients were diagnose in which 22 patients with tumor and 15 with non-tumor disease. The patients were intravenously injected small dose of HPD (2mg/kg). The fluorescence signal was analyzed with OMA system. Results: The fluorescence signal of low dose hematoporphyrin can use to diagnose cancer. The total of 37 patients, in which 22 patients suffered tumor, the average fluorescence peak of Itumor/Inomal was 1.24±0.08. We imitated a normal distributive curve, so that most ratio of Itumor/Inomal could be included in the scope of curve. Suppose the lower limit of diagnostic criterion was 1.05. accorded to the criterion 22 is tumor. 15 of them suffered non- tumor. The average of all Itumor/Inomal was 0.98±0.06, there is significant difference between normal and cancer. 13 of 15 is non-tumor, accorded to the criterion. The positive rate was 94.6%