A PET study of discrimination of cerebral glucose metabolism in Alzheimer's disease and mild cognitive impairment

2013 6th International Conference on Biomedical Engineering and Informatics Pub Date : 2013-12-01 DOI:10.1109/BMEI.2013.6746897

Haining Sun, Bin Hu, Zhijun Yao, M. Jackson

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引用次数: 5

Abstract

Imaging cerebral glucose metabolism with positron emission tomography (PET) has been widely used in studying Alzheimer's disease (AD) and mild cognitive impairment (MCI). In this study, we used fluoro-deoxyglucose (FDG) PET images to investigate reduced glucose metabolism in 90 AD subjects, 90 MCI subjects and 90 healthy elderly normal controls (NC). Compared to NC, the AD showed a significant hypometabolism in left and right middle temporal, left cingulate gyrus, medial frontal gyrus and left parahippocampal gyrus. Compared to NC, the MCI showed a significant hypometabolism in the right inferior temporal gyrus and right fusiform gyrus. Compared to MCIs, the AD also showed a significant hypometabolism in left and right middle temporal, left cingulate gyrus, left angular gyrus and right parahippocampal gyrus. This study demonstrates the different cerebral metabolic patterns of AD, MCI and controls. It also shows that glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and that might be valuable in predicting future cognitive decline.

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阿尔茨海默病与轻度认知障碍患者脑糖代谢鉴别的PET研究

利用正电子发射断层扫描(PET)成像脑葡萄糖代谢已广泛应用于阿尔茨海默病(AD)和轻度认知障碍(MCI)的研究。在这项研究中，我们使用氟脱氧葡萄糖(FDG) PET图像研究了90例AD受试者、90例MCI受试者和90例健康老年人正常对照(NC)的葡萄糖代谢降低。与NC相比，AD在左、右颞叶中部、左扣带回、左额叶内侧回和左海马旁回均表现出明显的代谢降低。与NC相比，MCI显示右侧颞下回和右侧梭状回代谢明显降低。与MCIs相比，AD在左、右颞中回、左扣带回、左角回和右海马旁回也表现出明显的代谢降低。本研究显示了AD、MCI和对照组不同的脑代谢模式。研究还表明，葡萄糖代谢是AD和MCI患者认知和功能能力变化的敏感指标，可能在预测未来认知能力下降方面有价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2013 6th International Conference on Biomedical Engineering and Informatics

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