Studies on Causes Inducing Positive Reaction in Self-Controls of Coombs Tests Carried Out as Cross-Matchings and on Transfusion Results in These Cases

Abstract

Self-control of indirect Coombs tests gave positive results at the frequency of 5. 5% (585 cases) among 10, 727 pretransfusion cross-matchings. Drugs (antibiotics, methyldopa) (46. 3%) , adsorption of complement along with antiI (17. 8%) , autoantibodies (3. 6%), and anti-A or anti-B (O. 7%) were the main causes of these positives. On the other hand, no such causes could be found in the remaining 30. 8%. In the 460 cases who received blood transfusion in spite of their positive self-controls, no clinical side effects were obserevd.