New formulations for realization and characterization of homogeneous tissue mimicking materials for HIFU exposures

2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings Pub Date : 2015-05-07 DOI:10.1109/MeMeA.2015.7145185

A. Troia, R. Cuccaro, A. Schiavi

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引用次数: 4

Abstract

In this paper a novel formulation for the realization of homogenous transparent and tunable attenuating tissue-mimicking materials (TMMs) has been reported. Although many hydrogel based materials have been proposed for high intensity ultrasonic field characterization, no one fully satisfies the requested acoustic and optical properties. Using concentrated salts solutions and different polysaccharide molecules, a simple preparation method has been developed to obtain this new class of TMMs. Physical properties of these TMMs have been investigated by an accurate mechanical and acoustic characterization. Furthermore, a short discussion about the mechanism of ultrasonic attenuation given by salts solutions embedded in polymeric matrix has been conducted. Finally, by means of an experiment on protein denaturation induced by HIFU, the different mechanism underlying lesions formation occurring in a transparent TMM with and without salt has been revealed. Shown results supply a new starting point for the production of TMMs suitable for HIFU characterization.

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用于HIFU暴露的均匀组织模拟材料的实现和表征的新配方

本文报道了一种实现均匀透明可调谐衰减组织模拟材料(TMMs)的新配方。虽然许多水凝胶基材料已被提出用于高强度超声场表征，但没有一种材料完全满足所要求的声学和光学性能。利用浓缩盐溶液和不同的多糖分子，开发了一种简单的制备方法，得到了这类新型的TMMs。通过精确的力学和声学表征研究了这些TMMs的物理性质。此外，还对盐溶液包埋在聚合物基体中的超声波衰减机理进行了初步探讨。最后，通过HIFU诱导的蛋白变性实验，揭示了含盐和不含盐透明TMM病变形成的不同机制。所显示的结果为生产适合HIFU表征的TMMs提供了新的起点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings

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