Nefropatía lúpica silente

Seminarios de la Fundación Espa?ola de Reumatología Pub Date : 2012-01-01 DOI:10.1016/j.semreu.2011.10.002

Montserrat M. Díaz Encarnación, José Ballarín Castan

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引用次数: 1

Abstract

Silent lupus nephritis (SLN) is an unusual clinical presentation of lupus nephritis (LN) and may be an underdiagnosed entity. Renal biopsy is the only diagnostic method but is invasive and is not indicated in asymptomatic patients. Consequently, the prevalence of this disease is difficult to determine. Data from more than 250 SLN cases published in the literature were analyzed from isolated cases, case studies and prospective studies. Of the 226 well-described cases, we selected 197 reported after the 1970s. Patients with class I lesions (n = 29, 15%) were excluded as they fell outside the definition of SLN. Among included patients, there were 107 with class II (54.3), 45 with class III (22.8%), 50 with class IV (25.4%), 9 with class V (4.6%) and one with class VI. Forty percent had proliferative forms (classes III and IV), the most severe forms of LN.

Of the 197 patients, 65 patients (33%) from six publications were followed-up. The data did not allow conclusions to be drawn on the epidemiology or prognosis of this entity. Future studies are required to clarify these issues.

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沉默性狼疮性肾炎(SLN)是狼疮性肾炎(LN)的一种不寻常的临床表现，可能是一种未被诊断的实体。肾活检是唯一的诊断方法，但它是侵入性的，不适用于无症状的患者。因此，这种疾病的流行程度很难确定。从孤立病例、案例研究和前瞻性研究中分析了文献中发表的250多例SLN病例的数据。在226例描述良好的病例中，我们选择了1970年代以后报告的197例。I级病变患者(n = 29,15 %)因超出SLN定义而被排除。在纳入的患者中，II类患者107例(54.3)，III类患者45例(22.8%)，IV类患者50例(25.4%)，V类患者9例(4.6%)，VI类患者1例。40%的患者为最严重的LN增生型(III类和IV类)。197例患者中，有65例患者(33%)接受了随访。这些数据不能得出关于该疾病流行病学或预后的结论。需要进一步的研究来澄清这些问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Seminarios de la Fundación Espa?ola de Reumatología

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