The link between genetic variation and variability in vaccine responses: a narrative review

Yingtian Zhang, Mingzhe Zhao, Wei Zhou, Luan Chen, Mo Li, Bixuan Jiang, Xianglong Zhao, Hao Wu, Lu Shen, Na Zhang, He Qin, Yuhao Tang, Chenhan Jia, Lin He, Shengying Qin
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引用次数: 5

Abstract

Abstract Vaccines are one of the biggest successes in modern history and are particularly important in light of the multiple ongoing epidemics. Recently, vaccines have protected peoples’ health and lives around the world during the coronavirus disease 2019 pandemic. Different types of vaccines have their own characteristics and advantages and are used in the context of different epidemics. Responses to vaccination are also different, and can include adverse reactions and absent responses. These individual differences are thought to be influenced by host genes. In this review, we first discuss vaccine types and characteristics. Second, we discuss different responses to vaccination, primarily focusing on the association between genetic variation and inter-individual differences.
基因变异与疫苗反应变异性之间的联系:叙述性综述
疫苗是现代历史上最大的成功之一,在多重持续流行的情况下尤为重要。最近,在2019年冠状病毒病大流行期间,疫苗保护了世界各地人民的健康和生命。不同类型的疫苗有其自身的特点和优势,适用于不同的流行病。对疫苗接种的反应也不同,可能包括不良反应和无反应。这些个体差异被认为是受宿主基因的影响。在这篇综述中,我们首先讨论了疫苗的类型和特点。其次,我们讨论了对疫苗接种的不同反应,主要集中在遗传变异和个体间差异之间的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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