Plant-based phytochemical mediated inhibition of breast cancer by targeting PLAT: An in-silico study

Abstract

Cancer refers to a group of diseases in which some cells of the body start growing abnormally and in an uncontrolled manner causing deaths in millions worldwide. Tumor cells spread or invade to other parts of body or tissue and the process is called metastasis. Genetic and environmental factors like arsenic, alcohol, and tobacco cause cancers in the human body. Studies show antioxidants have potential anticancer effects and are used to design therapeutic tactics to fight cancer. Several computational tools, including Autodock Vina, Pymol, Protein Drug Bank, and PILP, are used in this study. (Protein-Interaction Ligand Profiler). By using PILP and molecular docking of the protein and ligand, the interactions between Tissue type Plasminogen-Activator and plant phytochemicals are investigated. Drug discovery is facilitated by research into protein and ligand interactions. The purpose of this study is to identify the most effective plant phytochemicals that have demonstrated promise in preventing cancer in humans.