AKTIVITAS ANTIKANKER SENYAWA STILBENOID DARI DAUN Macaranga aleuritoides

Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Pub Date : 2019-06-02 DOI:10.35799/PMJ.2.1.2019.23606

Muhammad Fajar Aldin, Ratih Dewi Saputri, Tjitjik Srie Tjahjandarie, M. Tanjung

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引用次数: 2

Abstract

AKTIVITAS ANTIKANKER SENYAWA STILBENOID DARI DAUN Macaranga aleuritoides Muhammad Fajar Aldin1), Ratih Dewi Saputri1), Tjitjik Srie Tjahjandarie1), Mulyadi Tanjung1*)1)Kimia Organik Bahan Alam, Departemen Kimia, Fakultas Sains dan Teknologi, Universitas Airlangga, Surabayamulyadi-t@fst.unair.ac.id ABSTRACT Macaranga aleuritoides is one of species belongs to Euphorbiaceae family. Macapruinosin A (1) is one stilben derivatives with an irregular sesuiterpenyl side chain was isolated from the leaves of Macaranga aleuritoides. The structure of the isolated compound were determined by spectroscopic methods, including UV, IR, 1D and 2D NMR. The anticancer activity of macapruinosin A towards murin P-388 cells showed IC50 value of 1.65 μg/mL and showed high activity.Keywords : Macaranga aleuritoides, macapruinosin A, stilbenoid, anticancer. ABSTRAK Macaranga aleuritoides merupakan salah satu spesies tumbuhan dari famili Euphorbiaceae. Makapruinosin A, senyawa turunan stilben dengan rantai samping seskuiterpen tak teratur telah diisolasi dari daun M. aleuritoides Struktur senyawa tersebut ditetapkan berdasarkan analisis spektroskopi,meliputi UV, IR, 1D dan 2D NMR. Uji aktivitas antikanker senyawa makapruinosin A terhadap sel murin P-388 memperlihatkan nilai IC50 sebesar 1,65 μg/mL dan dikategorikan sangat aktif. Kata kunci : Macaranga aleuritoides, makapruinosin A, stilbenoid, antikanker.

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从阿留利欧水螅叶中沿植物生长的抗癌活性

Muhammad Fajar Aldin1), Ratih Dewi Saputri1), Tjitjik Srie Tjahjandarie1), Mulyadi Tanjung1*)1)Organic Chemistry of Natural Materials, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabayamulyadi-t@fst.unair.ac.id ABSTRACT Macaranga aleuritoides 是大戟科植物之一。从 Macaranga aleuritoides 的叶子中分离出的 Macapruinosin A (1) 是一种具有不规则芝麻戊基侧链的二苯乙烯衍生物。通过紫外、红外、一维和二维核磁共振等光谱方法确定了所分离化合物的结构。大果芸香苷 A 对小鼠 P-388 细胞的抗癌活性 IC50 值为 1.65 μg/mL，显示出较高的活性：Macaranga aleuritoides 大果芸香苷 A 麦冬苷抗癌Macaranga aleuritoides 是大戟科植物之一。通过紫外、红外、一维和二维核磁共振等光谱分析，确定了该化合物的结构。大果芸香苷 A 化合物对 P-388 小鼠细胞的抗癌活性测试显示，其 IC50 值为 1.65 μg/mL，属于高活性化合物。关键词Macaranga aleuritoides 大果芸香苷 A 类芪类化合物抗癌

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Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ)

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