Design considerations for on-chip THz analysis of biomolecules

Abstract

Recently the marker free distinction between different kinds of biomolecules, e.g. hybridised (double-stranded) DNA (HDNA) and denatured (single-stranded) DNA (DDNA) using THz time-domain on-chip analysis has been demonstrated. Here we numerically examine the influence of critical experimental parameters on the transmission characteristics of a variety of microstrip resonators loaded with test samples of different thickness and refractive index.