A CMOS integrated circuit for DNA hybridization detection with digital output and temperature control

Abstract

A CMOS integrated circuit hosting an array of 80 sensors for DNA hybridization detection was designed. Each biosensor is made up of a FET device whose current is modulated by DNA electric charge. The chip incorporates integrated temperature detection for precise assay control and features programmable signal conditioning, amplification and A/D conversion. Successful pre- and post-layout simulations are provided.