Pathophysiology of NAMPT in the progression and suppression of heart related diseases

International Journal of Science and Technology Research Archive Pub Date : 2023-05-30 DOI:10.53771/ijstra.2023.4.2.0059

Nebechukwu William Eneh, Etinosa Bright Ovabor, Joel Oluwamurewa Olayemi, Kelechi Charity Nnadi, Sofia Hussein Suleiman

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Abstract

Nicotinamide phosphoribosyltransferase (NAMPT) is an important enzyme that catalyzes nicotinamide adenine dinucleotide (NAD) biosynthesis. NAMPT and NAD are vital for maintaining cellular redox homeostasis and modulation of cellular metabolism. However, the role of NAMPT in the pathophysiology of heart related diseases is not clearly understood but different researchers have over the years tried to explain the actual role of NAMPT in the occurrence of heart diseases. High-circulating levels of NAMPT are reported in different pathological conditions. Extracellular NAMPT is a proinflammatory cytokine that has attracted a considerable attention recently with respect to induction of cardiovascular diseases. Furthermore, studies have also revealed that NAMPT play a very important role in combating NAD depletion in the presence of NAD consuming enzymes, hence preventing the onset of pathological cardiac hypertrophy. This review further explained in detail the role of NAMPT in the progression and suppression of heart diseases as well as cardiovascular diseases.

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NAMPT在心脏相关疾病进展和抑制中的病理生理学

烟酰胺磷酸核糖基转移酶(NAMPT)是催化烟酰胺腺嘌呤二核苷酸(NAD)生物合成的重要酶。NAMPT和NAD对于维持细胞氧化还原稳态和调节细胞代谢至关重要。然而，NAMPT在心脏相关疾病的病理生理中的作用尚不清楚，但多年来不同的研究者试图解释NAMPT在心脏病发生中的实际作用。高循环水平的NAMPT在不同的病理条件下被报道。胞外NAMPT是一种促炎细胞因子，最近在心血管疾病的诱导方面引起了相当大的关注。此外，研究还表明，在NAD消耗酶存在的情况下，NAMPT在对抗NAD消耗方面发挥着非常重要的作用，从而防止病理性心肌肥厚的发生。本文将进一步详细阐述NAMPT在心脏病和心血管疾病的进展和抑制中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Science and Technology Research Archive

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