Estimation of the concentration of some biomarkers in serum of women with rheumatoid arthritis

Abstract

The current study was conducted on women with rheumatoid arthritis (RA) in Basrah city, Iraq. The study aimed to evaluate the relationship between some biomarkers such as adiponectin hormone, anti-citrullinated protein antibody (ACPA), acute phase C-reactive protein (CRP) and vascular endothelial growth factor (VEGF) in the serum of female patients. In this study, 80 serum samples were collected from women and were distributed as follows: 56 serum samples from women with RA and 24 serum samples from non-infected women who were considered as a healthy group. The patient samples were divided into three categories depending on age, disease severity and duration. The samples were obtained from Basrah General Hospital. The results of the current study showed a significant increase in the concentration of adiponectin, ACPA, CRP and VEGF in RA patients compared to healthy subjects. In addition, there were significant differences in the concentration of these biomarkers between some of the three age groups and between the disease of severity and duration. The study concluded that all the biomarkers under investigation have increased their concentrations in the serum of women suffering from RA.