Breast Cancer Drug Repurposing a Tool for a Challenging Disease

Jonaid Ahmad Malik, Rafia Jan, S. Ahmed, Sirajudheen Anwar
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引用次数: 6

Abstract

Drug repurposing is one of the best strategy for drug discovery. There are several examples where drug repurposing has revolutionized the drug development process, such as metformin developed for diabetes and is now employed in polycystic ovarian syndrome. Drug repurposing against breast cancer is currently a hot topic to look upon. With the continued rise in breast cancer cases, there is a dire need for new therapies that can tackle it in a better way. There is a rise of resistance to current therapies, so drug repurposing might produce some lead candidates that may be promising to treat breast cancer. We will highlight the breast cancer molecular targets, currently available drugs, problems with current therapy, and some examples that might be promising to treat it.
乳腺癌药物重新定位一种具有挑战性的疾病的工具
药物再利用是药物发现的最佳策略之一。有几个例子表明,药物再利用已经彻底改变了药物开发过程,比如开发用于糖尿病的二甲双胍,现在用于治疗多囊卵巢综合征。乳腺癌药物再利用是目前研究的热点。随着乳腺癌病例的持续增加,迫切需要新的治疗方法来更好地解决这个问题。对现有疗法的耐药性正在上升,因此药物再利用可能会产生一些有望治疗乳腺癌的主要候选药物。我们将重点介绍乳腺癌的分子靶点,目前可用的药物,目前治疗的问题,以及一些可能有希望治疗它的例子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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