Dose-dependent vitamin D3, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3-induced hypercalcemia and hyperphosphatemia, and the correlative changes in the activity of ultimobranchial and parathyroid glands of the toad, Bufo andersoni Boulenger.

Biological structures and morphogenesis Pub Date : 1992-01-01

K Swarup, A K Pandey, N Hasan, V K Das

引用次数: 0

Abstract

Vitamin D3, 25(OH) vitamin D3 and 1,25 (OH)2D3 were administered daily to unfed male Bufo andersoni for 15 days which resulted in a significant hypercalcemia and hyperphosphatemia in a dose-dependent fashion. 1,25(OH)2D3 is more potent than the other metabolites. The treatment activated ultimobranchial gland but induced degenerative changes in parathyroid of the toads.

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剂量依赖性维生素D3、25-羟基维生素D3和1,25-二羟基维生素D3诱导蟾蜍高钙血症和高磷血症及甲状旁腺和鳃旁腺活性的相关变化

在连续15天的试验中，研究人员对未喂食的雄性大鲵每天给予维生素D3、25(OH)维生素D3和125 (OH)2D3，结果显示它们出现了明显的高钙血症和高磷血症，且呈剂量依赖性。1,25(OH)2D3比其他代谢物更有效。治疗激活了鳃旁腺，但诱导了甲状旁腺的退行性改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biological structures and morphogenesis

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