Phytochemicals And Nutraceuticals as A Promising Drug Candidate in Autism Spectrum Disorder

Abstract

Autism is a diversified group of neurological disorders having unknown cause which are interpreted entirely based on behavioral examination. During the last two decades, the frequency and prevalence rate of autism spectrum disorder (ASD) have risen. The elevated level of oxidative stress and reduced antioxidant potential has been associated with this disorder. Further in autism, the genetic as well as environmental determinants may escalate susceptibility to oxidative stress. Elevated oxidative stress in ASD give rise to the development of this disorder regarding both clinical manifestations and pathological process. Autism manifests the characteristics like changes in complicated human behaviors which includes social interaction, communication and stereotypies. In addition, children suffering from autism may not be able to cope anxiety and behave unreasonably even to otherwise benign stimulators. It is proposed by growing evidence that epigenetic mechanisms play a role in the etiology of autism. To detect epigenetic biomarkers for ASD, numerous studies have endeavored until now. Children having autism spectrum disorder (ASD) usually show remarkable behavioral difficulties in combination with dysfunction in social relationship