Expression of resistin in serum of TAO patients

Abstract

BackgroundResistin is the member of human cytokines,but its function is below understood.Research revealed that the expression of resistin in serum is regulated by sexual gland,thyroid hormone.ObjectiveThe goal of this study was to investigate the expression of resistin in the serum of TAO patients.MethodsThe serum samples were obtained from 35 patients with thyroid-associated ophthalmopathy(TAO).These patients rejected the administration of glucocorticoid and immunity inhibitor within 3 months and were assigned to inactive TAO group(CAS4,18 cases)and active TAO group(CAS≥4,17 cases).Fifteen normal subjects were as control group.The level of resistin in serum was detected using ELISA kit.Written informed consent was obtained from each individual at initial of the medical process.Results No significant difference was found in serum resistin level between inactive TAO group and active TAO group(12.103±5.042 versus 13.470±3.749)mg/L(t=0.906,P=0.371).However,serum resistin level was significant declined in inactive TAO group or active TAO group in comparison with normal group(12.103±5.042 versus 21.894±10.589;13.470±3.749 versus 21.894±10.589)mg/L(t=3.074,P=0.004;t=3.485,P=0.001).No obvious difference was seen between male patients and female patients(13.175±4.483 versus 12.335±4.511)mg/L(t=0.552,P=0.585).Serum resistin level was gradually elevated with the increase of age in TAO patients(F=24.978,P=0.000).ConclusionThe serum resistin level of TAO patients is lower than the control subjects,suggesting that the level of serum resistin is regulated by thyroid hormones.The serum resistin level increases with age in TAO patient.