The Modified Mathematical Model of Arteriosclerosis onset: Adding the Effect of Repairing Flaws of the Intima

Abstract

The mathematical model of arteriosclerosis onset is modified adding the effect of repairing flaws of the intima. Numerical simulations of the modified mathematical model reveal that the effect of repairing flaws of the intima suppresses the progression of arteriosclerosis. And the numerical simulations also reveal that the rapider improving the number of flaws per unit area of the intima, the greater the degree to which the reduction of the volume of the blood vessel in the arteriosclerosis-causing part is suppressed. However, in case for example the cholesterol concentration in blood is high, the effect of suppressing the progression of arteriosclerosis is small. These results will provide quantitative suggestions for clinical treatment.