Intravenous Levetiracetam in Refractory Status Epilepticus

Abstract

Refractory status epilepticus is defined as seizures, which last longer than 60 minutes despite treatment with a benzodiazepine and an adequate loading dose of intravenous antiepileptic drug. 1It has a high mortality and requires prompt management. Currently available drugs like midazolam, pentobarbitol and propofol can cause hypotension and respiratory depression. We present control of Refractory status in three critically ill patients using intravenous levetiracetam, which has a unique drug profile.