Effect of Lamun Leaves [Enhalus acoroides (L.f.) Royle] on Leydig Cell Morphology

Abstract

The ageing male process lead deterioration fertilization ability that caused of Leydig cell degeneration by an accumulation of oxidative stress with decreased testosterone levels. Enhalus acoroides contains antioxidants and phytosterols which can be converted into testosterone. The aim of this study to investigate the extract of Enhalus acoroides effect on Leydig cell morphology in male mice. Male mice was divided into 8 groups: adult mice no treatment (AG1), adult mice with olive oil (AG2), adult mice with extract of Enhalus acoroides at dose 25 mgKg-1 (AG3), adult mice with extract of Enhalus acoroides at dose 50 mgKg-1 (AG4), old mice no treatment (OG1), old mice with olive oil (OG2), old mice with extract of Enhalus acoroides at dose 25 mg Kg-1 (OG3), and at dose 50 mgKg-1 (OG4). All groups were repeated for 14 days. There was a significantly increased number of old Leydig cells in old mice group and adult mice group at dose 25 mgKg-1 compared without treatment. There is no difference in the observation of adult Leydig cell degeneration.