A global methodology for modeling and simulating medical systems

C. El-Gemayel, F. Jumel, N. Abouchi, J. Constantin, Doumit Zaouk
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Abstract

A mathematical representation of patient or device is presented by a number of variables which are defined to represent the inputs, outputs and a set of equations describing the interaction of these variables. This paper proposes a global methodology for modeling and simulation medical systems and human body, in order to analyze the performance and the quality of services of all system components. Beginning by defining a new prototype of a global and flexible architecture of mathematical model of human body, that is able to contain required data. Then, describing the simulations representation, by mentions in details the core simulator components, analyzer, and the quality of services indicators. Simulation of mathematical models provides useful tools for diagnosis and analyzing the interactions between efficacy, therapies, side-effects, and outcomes. This will help to better understand the human organism control, to analyze experimental data, to identify and quantify relevant biophysical parameters and to design clinical trials.
建模和模拟医疗系统的全球方法
病人或设备的数学表示是由许多变量来表示的,这些变量被定义为表示输入、输出和一组描述这些变量相互作用的方程。本文提出了一种对医疗系统和人体进行建模和仿真的全局方法,以分析系统各组成部分的性能和服务质量。首先定义一个新的原型,一个全球性的和灵活的人体数学模型的架构,能够包含所需的数据。然后,通过详细介绍模拟器的核心组件、分析器和服务质量指标,描述了仿真的表示。数学模型的模拟为诊断和分析疗效、治疗、副作用和结果之间的相互作用提供了有用的工具。这将有助于更好地理解人体有机体控制,分析实验数据,识别和量化相关的生物物理参数,并设计临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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