Comparison of Xpert MTB/RIF and GenoType MTBDRplus for rapid diagnosis of tuberculosis

Abstract

Xpert MTB/RIF (Cepheid) and GenoType MTBDRplus (Hain Lifescience) are two widely used tests for rapid diagnosis of tuberculosis. The aim of this study is to compare Xpert MTB/RIF and GenoType MTBDRplus to determine overall accuracy of diagnosis using these two tests. Based on search on PubMed, Embase and Google Scholar databases, publications were identified that compared Xpert MTB/RIF and GenoType MTBDRplus on the same dataset. A total of 6 studies with 4921 specimens were selected. Based on sensitivity and specificity, a pooled estimation of diagnostic odd ratio (DOR) and area under summary ROC curve (AUC) was calculated based on Random-Effect model. Both assays showed encouraging results for tuberculosis diagnosis but Xpert MTB/RIF depicted slightly better results based on recent studies.