Case 59: Small Fiber Neuropathy and Autonomic Failure with Elevated Voltage-Gated Potassium Channel Antibodies

Abstract

This case demonstrates severe autonomic failure associated with autoimmune small fiber neuropathy that was positive for elevated voltage-gated potassium channel (VGKC) antibodies. Adrenergic autonomic failure is associated with orthostatic hypotension. Low cerebral blood flow velocity during the tilt was associated with cerebral vasoconstriction.