[A double-blind study of metoclopramide in the treatment of schizophrenia and determination of prolactin].

Abstract

This paper reported that 40 schizophrenic patients treated with metoclopramide and haloperidol respectively with double blind observation. Dosage of these two drugs were 450 = 133 mg and 32 +/- 9.2 mg everyday respectively. The effect of metoclopramide were that: 67.5% (27/40) of patients had marked improvement and 85% (34/40) improvement. And the effect of haloperidol were 65% (26/40) and 80% (32/40) respectively. Both of these two drugs had no significant difference. Their main side effect was extrapyramidal reaction, and metoclopramide was milder in this. Detecting serum prolactin before and after treatment in 6 cases of metoclopramide therapy and 5 cases of haloperidol therapy. The ratio of serum levels of prolactin before and after treatment was 3.58 and 4.86 in both drugs therapy respectively.