Hepatitis B Virus Subtype Distribution in Bangladeshi Chronic Carriers

Northern International Medical College Journal Pub Date : 2018-11-23 DOI:10.3329/nimcj.v9i2.38908

Bushra Tanzem, S. Tabassum, S. Munshi, M. Jahan

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Abstract

Background : Hepatitis B virus (HBV) infection is one of the major global health problems and this virus has many variants that differ from epidemiological distributions, transmission sources, clinical outcomes, diagnostic assays as well as therapeutic responses. HBV was also divided into 9 different subtypes which has distinct geographical distributions and important for the epidemiological studies and vaccine development.Objective : Bangladesh is an intermediate prevalence region for HBV infection, however, very little is known about the incidence of HBV subtypes in circulation. Therefore, we investigated the HBV subtype distribution in Bangladesh.Method : A small cohort was performed on between March 2014 and August 2017 with 172 HBV DNA positive patients from the BSMMU. From them, 29 HBV DNA samples were isolated for sequencing by Sanger method. HBsAg subtypes were determined by identifying of 226 amino acid (aa) positions in the small surface (S) gene.Result : Our study showed that HBV subtype adrq+ was in 17 (58.6%) isolates, ayw3 in 8 (27.5%), ayw2 in 2 (6.9%) and adw2 in 2 (6.9%) isolates.Conclusion : We conclude subtype adrq+ predominant in Bangladesh. This was followed by ayw3, while adw2 and ayw2 were least dominant. Subtype adw2 and adrq+ strains are found to be related with more complication, therefore, patients infected with these HBV strains need to be careful monitoring to assess their clinical outcome in future.Northern International Medical College Journal Vol.9(2) Jan 2018: 286-290

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乙型肝炎病毒在孟加拉国慢性携带者中的亚型分布

背景:乙型肝炎病毒(HBV)感染是全球主要的卫生问题之一，这种病毒有许多变体，在流行病学分布、传播来源、临床结果、诊断分析和治疗反应方面各不相同。乙型肝炎病毒还分为9种不同的亚型，它们具有不同的地理分布，对流行病学研究和疫苗开发具有重要意义。目的:孟加拉国是HBV感染的中等流行区，然而，对循环中HBV亚型的发病率知之甚少。因此，我们调查了HBV亚型在孟加拉国的分布。方法:在2014年3月至2017年8月期间，对172名来自BSMMU的HBV DNA阳性患者进行了小队列研究。从中分离29份HBV DNA样本，采用Sanger法进行测序。通过对小表面(S)基因226个氨基酸(aa)位置的鉴定，确定HBsAg亚型。结果:HBV亚型adrq+ 17株(58.6%)，ayw3 8株(27.5%)，ayw2 2株(6.9%)，adw2 2株(6.9%)。结论:adrq+亚型主要发生在孟加拉国。其次是ayw3，而adw2和ayw2最不占优势。发现adw2和adrq+亚型与更多的并发症相关，因此，需要对感染这些HBV毒株的患者进行仔细监测，以评估其临床预后。北方国际医学院学报Vol.9(2) Jan 2018: 286-290

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Northern International Medical College Journal

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