Pharmacokinetics of dodecanedioic acid in rat

Abstract

The use of medium-chain dicarboxylic acjds, azelaic and sebacic acid, as energy substrates in total parenteral nutrition W M recently proposed [ 1 ,2\ , since these acids may have metabolic advantages over long-chain and medium-chain triglycerides. However, a large amount of the administered dose of azelaic and sebacic acid is excreted in the urine, so that the suitability of these acids in parenteral nutrition appears to be doubtful in terms of energetic yield [3,4]. Encouraging results were obtained in rat with the dodecanedioic acid (C12), which presents very low urinary excretion 151. In this paper we analyze the data in ( 5 ) by inems of a pharmacokinetic model with saturable tissue uptake, using an estimation method that tnkes into account the interindividual variability of in ode1 par nine t ers .