Cell Deformability Studies for Clinical Diagnostics: Tests with Blood Analogue Fluids using a Drop based Microfluidic Device

A. Moita, C. Caldeira, F. Jacinto, R. Lima, E. J. Vega, A. Moreira
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引用次数: 3

Abstract

The present paper addresses the final tests (concerning the transport section) of a microfluidic device to be used in cancer diagnostics, based on the mechanical properties of the cells and particularly on deformability. Following the previous work, which established the materials to be used, according to the wetting properties and their influence on the dynamic response of the droplets (which are electrostatically actuated) this paper presents the final simulations to optimize the thickness and material of the dielectric coating, always as a function of the dynamic response of the droplets. Then, to avoid contamination issues, a number of analogue fluids are proposed, in a new approach, which are characterized and tested in the second part of the work. Regarding the characterization of these new fluids, preliminary results suggest a great potential of a surfactant solution to be used as an analogue. The addition of the surfactant results in the formation of semirigid particles with a size distribution and deformation characteristics compatible with those of the biosamples to be studied. The surfactant solution also shows a swift response to electrostatic actuation.
用于临床诊断的细胞变形性研究:使用基于液滴的微流体装置对血液模拟流体进行测试
本文根据细胞的力学特性,特别是可变形性,介绍了一种用于癌症诊断的微流体装置的最终测试(关于传输部分)。在之前确定了所用材料的基础上,根据润湿特性及其对液滴(由静电驱动)动态响应的影响,本文提出了最终的模拟,以优化介电涂层的厚度和材料,并始终将其作为液滴动态响应的函数。然后,为了避免污染问题,以一种新的方法提出了一些模拟流体,并在工作的第二部分对其进行了表征和测试。关于这些新流体的表征,初步结果表明,表面活性剂溶液有很大的潜力用作类似物。表面活性剂的加入导致半刚性颗粒的形成,其尺寸分布和变形特征与待研究的生物样品相一致。表面活性剂溶液也表现出对静电驱动的快速响应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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