Immunomodulation with Adipose and Bone Marrow-derived Mesenchymal Stem Cells in Vascularized Composite Allotransplantation

Abstract

Reconstructive transplantation is a clinical reality. Graft sustenance requires life-long immunosuppression with coincident adverse effects. Therapies incorporating adipose tissueand bone marrow-derived mesenchymal stem cells (AD-MSC/BM-MSCs) have shown promising effects in experimental autoimmune diseases, solid organ transplantation and vascularized composite allotransplantation (VCA). Clinical translation of these therapies must consider collateral effects of depletional conditioning protocols. For the first time, we compare AD-MSCs versus BM-MSCs in VCA.