Рrevention of reproductive diseases in animals with the use Nanobiomaterials

Abstract

The aim of the work was to develop methods for the prevention of reproductive pathologies using drugs containing nanobiomaterials. This is due to the fact that the physiological functioning of the reproductive organs is rich in the state of the antioxidant defense system, the main active component of which are antioxidants that neutralize the negative effects of free radicals – specific products of cell life and their damage factors. Work on the development and manufacture of drugs was performed on the basis of the Department of Veterinary Reproductology of the State Biotechnology University (Kharkov) and the Department of Nanocrystalline Materials of the Institute of Scintillation Materials (Kharkov), implementation – in farms of various forms of ownership. Developed methods for the prevention of reproductive pathologies of animals (normalization of the structure and function of the fetoplacental complex of cows and sheep and increase the development potential of newborn calves and lambs, increase the reproductive capacity of bulls and boars) are based on the use of vitamin and hormonal drugs «Caplaestrol + OV», «Carafest + OV» and «Carafand + OV» containing nanobiomaterial – gadolinium orthovanadate activated by europium, the nanoparticles of which are able to penetrate cells and accumulate in nuclei. The obtained data allow us to conclude that the use of nanobiomaterials ensures the effectiveness of programs for the prevention of reproductive pathologies of animals. In particular, the method of normalizing the structure and function of the fetoplacental complex of cows and sheep and increase the development potential of newborn calves and lambs provides an increase in placental weight by 23,4-24,3 %, newborn weight – by 18,6-29,6 %, increase in the number of cotyledons by 2,9-3,0 % and the area of the hairy part of the chorion – by 13,3-34,7 %, and the method of increasing the reproductive capacity of bulls and boars allows to increase the volume of ejaculate by 4,2-28,7 %, increase sperm motility by 16,7-28,1 %, sperm concentration – by 4,8-13,6 %, testosterone levels – by 16,8-44,2 % and reduce the number of sperm with morphological abnormalities by 1,6-2,4 %.